Reverb Therapeutics

Fighting Cancer Smarter

Reverb creates medicines that intelligently reshape the body’s immune system to fight cancer and other life-threatening conditions more effectively.

Amplify•R™ is our platform that adjusts the volume and resets the tuning on the body’s natural immune system.

When the body’s own cytokines are redirected to where they are needed, we achieve positive clinical benefits without the harm associated with exogenous cytokines. Amplify•R effectively rewires the immune system, boosting the body’s natural signals to achieve clinical effect without harm.

Built on deep understanding of the immune system and modeled with AI, Amplify•R boosts the function and extends lifespan of T-cells, resulting in serial killing of tumor cells.

Media for Reverb's Bispecific Antibody Platform Amplifies Natural Cytokine Signaling.
Reverb's Bispecific Antibody Platform Amplifies Natural Cytokine Signaling.

Reverb Development Pipeline

Compound Target Concept Concept Lead Development Lead Development IND Enabling IND Enabling Phase 1 Phase 1
Amp01 IL-15
Directed to PD-1+ T Cells
IND Enabling
Amp02 IL-15
Directed to relevant tumor associated antigens
Lead Development
Amp03 Undisclosed
Autoimmune program
Lead Development
Amp04 Undisclosed
Cell therapy support program
Lead Development
Additional programs IL-15 Capture
and redirecting arms
Concept
Most current approaches to boosting the body’s immune system rely on external, engineered molecules. But they trigger systemic toxicity and dangerous immune responses. Amplify•R™ helps the body fight smarter, not harder.

Our Investors

Image of Bharat Srinivasa, Ph.D.
"Reverb's Amplify•R™ platform brings a groundbreaking approach to cytokine biology, unlocking powerful, game-changing therapies for patients and reducing systemic toxicity and immunogenicity."
Bharat Srinivasa, Ph.D. Co-founder and Principal, Amplitude Ventures
Image of Stephanie Oestreich, Ph.D.
"Our investment in Reverb supports our strategy to fund companies that improve myeloma patients’ immune response. A successful therapy in this area will bring us further on the path to a cure."
Stephanie Oestreich, Ph.D. Managing Director, Myeloma Investment Fund
Image of Pierre Beauparlant, Ph.D.
"FHV invested in Reverb Therapeutics for its differentiated and highly innovative use of bispecific antibodies to address the core limitations of cytokine therapies."
Pierre Beauparlant, Ph.D. Executive Managing Director, Finchley Healthcare Ventures
Image of Thomas Park, MBA
"Reverb's antibody-based platform, and its promising potential to treat serious diseases, is a perfect example of the exciting life sciences innovations taking place in British Columbia."
Thomas Park, MBA Chief Investment Officer, InBC
  • Logo for Amplitude
  • Logo for Kdt Ventures
  • Logo for Myeloma Investment Fund
  • Logo for Finchley
  • Logo for Seido Capital
  • Logo for inBC

Science/Updates

Access our press releases, posters or other publications.

SITC 2025 Poster – Amplification & Redirection of Endogenous IL-15 Activity with a Bispecific Anti-PD1 Antibody

View PDF about SITC 2025 Poster – Amplification & Redirection of Endogenous IL-15 Activity with a Bispecific Anti-PD1 Antibody

AACR 2025 Poster – Bispecific Antibody-based Redirection of Endogenous IL-15 to PD-1+ Cells Enhances Antitumor Activity Over Checkpoint Inhibition Alone

View PDF about AACR 2025 Poster – Bispecific Antibody-based Redirection of Endogenous IL-15 to PD-1+ Cells Enhances Antitumor Activity Over Checkpoint Inhibition Alone